Python remains one of the most popular languages for building data science applications given its simplicity and widespread support for open-source data science projects. While it is easy to integrate such projects into your own Python applications, the CI/CD pipeline of the applications will become heavier and more tightly coupled, even in a modern containerized infrastructure. PyPI Cloud is an open-source private PyPI server which enables users to store and distribute their own Python packages in a cloud-native way. Not only does it provide easy-to-use package management similar to public PyPI, it also helps users build flexible and manageable Python applications by decoupling the CI/CD process of Python packages from application containerization. This talk explores how you can design cloud infrastructure that allows developers to focus on writing interesting Python code without worrying about how to build, deploy, or distribute it. By using a real world example, we will understand strategies to improve each step of the CI/CD pipeline for your Python applications using PyPI cloud.